PreSonus Studio 2|6 USB Audio Interface (Discontinued)


87 out of 100. Incorporating 60+ ratings and reviews.

Street Price: 

PreSonus Studio 2|6 USB Audio Interface
PreSonus Studio 2|6 USB Audio Interface

With its 2-in/4-out configuration, the PreSonus Studio 2|6 allows for two channel real-time recording and versatile monitoring.

At its core are two XMAX-L solid-state preamps, both of which run on standard USB bus power while providing good headroom.

For monitoring, PreSonus equipped this unit with Cue Mix A/B functionality, wherein you can switch between two sound sources conveniently.

Finally, it comes with 5-pin MIDI connectivity for compatibility, a feature that many users request.


  • A/D Resolution: 24-bit/192kHz
  • Preamp: 2 x XMAX-L Preamps
  • Channels: 2
  • Inputs: 2 x XLR-1/4" combo (Mic/Line)
  • Outputs: 2 x 1/4", 2 x 1/4" (Line Out), 1 x 1/4" (Headphones)
  • MIDI: In/Out, USB
  • Power: USB Bus Powered
  • Phantom Power: 48V
  • Bundled Software: PreSonus Studio One Artist, PreSonus Studio Magic Plug-in Bundle


Thanks to its balance of quality, functionality and pricing, the PreSonus Studio 2|6 continues to be well received. Superlatives like fantastic, best and great are often used to describe its overall value, with special mention of its preamp quality. A lot of users are also satisfied with its versatile output and monitoring options.


Most of the complaints point to issues installing or setting up the bundled software, which may be user error. Thankfully, the hardware itself gets no serious complaints.


The PreSonus Studio 2|6 was on our recommended list until we undertook a major review of sub $200 interfaces in December 2019 when we found there were more highly rated options available which you can see in our guide to The Best Cheap Audio Interfaces including the PreSonus AudioBox USB 96.